She made her debut in the Bengali film Tomake Salam released in 2003. She moved to South Indian film industry with the Tamil film Kokki which did not show promising results in the box-office. She has also acted in Dhamad Ke Intizaar and has even finished a Tamil film Vaitheeswaran opposite Sarath Kumar.
She entered the Kannada film industry with Mungaaru Male which was a big hit in Karnataka. Following this movie, she was an ad-model for several shaving cream advertisements.
Pooja Gandhi has also acted in the Kannada movie Krishna, opposite "Comedy Time" Ganesh her co-actor in Mungaaru Male.